The effect of miotics on the intraocular pressure of conscious owl monkeys.
نویسندگان
چکیده
The intraocular pressure of conscious, unsedated owl monkeys (Aotus trivirgatus) was measured with an applanation tonometer. Untreated eyes of the conscious animals were found to have higher values than those reported for owl monkeys anesthetized with pentobarbitone. Locally applied pilocarpine, carbachol, and oxotremorine gave concentration-related reduction in pressure, oxotremorine being the most potent and having longer duration of effect than the other compounds. Slight reductions were also observed with aceclidine and R. S. 86. These results are discussed in relation to the effects of miotics in man.
منابع مشابه
The effect of miotics on the intraocular pressure of conscious owl monkeys
1. Nissen, O. I., and Hoppe, R.: The facility of aqueous outflow calculated from the rate of fall in applanation pressure after intravenous acetazolamide in man, Acta Ophthalmol. 52: 390, 1974. 2. Nissen, O. I.: The immediate response in applanation pressure to intravenous acetazolamide in primary glaucomas and glaucoma suspects, Acta Ophthalmol. 53: 537, 1975. 3. Grant, W. M.: Tonographic meth...
متن کاملComparison of the hypotensive and other ocular effects of prostaglandins E2 and F2 alpha on cat and rhesus monkey eyes.
It is generally accepted that exogenous or endogenous prostaglandins (PGs) can give rise to acute increases in intraocular pressure (IOP) and to the development of flare and other signs of uveitis. It was recently shown, however, that low doses of PGE2 and/or PGF2 alpha topically applied to rabbit or owl monkey eyes significantly reduce IOP. The present experiments show that topical application...
متن کاملEffect of Prosfaglandin F2a on Aqueous Humor Dynamics of Rabbit, Cat, and Monkey
Topical administration of prostaglandin F2a (PGF2a) produced a reduction in intraocular pressure in eyes of rabbits, cats, and cynomolgus monkeys. In rabbit eyes at 5 or 6 hr, 50 ng, 100 ng, or 250 ng of PGF2a caused a significant intraocular pressure reduction with a small miotic effect. Treatment with 500 ng, 750 fig, or 1000 ng of PGF2a lowered intraocular pressure significantly in cat eyes ...
متن کاملThe effect of low dose of ketamine on intraocular pressure in patients undergoing cataract surgery
Background: Cataract surgery is one of the most common surgeries in the world, especially in elderly patients, and often performed topically with sedative agents. Ketamine is one of the most commonly used agents and the effect of different doses on intraocular pressure is in dispute. The present study investigates the effect of a low dose of ketamine on intraocular pressure in patients undergoi...
متن کاملEffect of Calcium Channel Blockers on Intraocular Pressure in Rabbits
The objective of the study was to evaluate the antiglaucoma effect of calcium channel blockers diltiazem and verapamil. Albino rabbits were used and chronic glaucoma was induced in them using freshly prepared 150 units of alphachymotrypsin. 0.1 mL of drug solution was administered topically into the left eye whereas the right served as control. The pressure recording was carried out at 15, 30, ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Investigative ophthalmology
دوره 15 10 شماره
صفحات -
تاریخ انتشار 1976